Switching biologic agents for uveitis
نویسندگان
چکیده
منابع مشابه
Update on the use of systemic biologic agents in the treatment of noninfectious uveitis
Uveitis is one of the leading causes of blindness worldwide. Noninfectious uveitis may be associated with other systemic conditions, such as human leukocyte antigen B27-related spondyloarthropathies, inflammatory bowel disease, juvenile idiopathic arthritis, Behçet's disease, and sarcoidosis. Conventional therapy with corticosteroids and immunosuppressive agents (such as methotrexate, azathiopr...
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This paper reviews the new biologic agents that selectively block the immunologic steps implicated in the pathogenesis of psoriasis. Four strategies have been targeted: reduction of the number of pathogenic T cells; inhibition of T-cell activation and migration; modulation of the immune system; and blockage of the activity of inflammatory cytokines. There are three classes: monoclonal antibodie...
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Methods A systematic search between January 2000 and May 2013 was conducted using EMBASE, Ovid MEDLINE, Evidence Based Medicine Reviews-ACP Journal Club, Cochrane libraries, and EBM Reviews. Studies investigating the efficacy of anti-TNFa therapy, as the second biologic treatment for ACU, in children (≤16 yrs) refractory to a first course of a single anti-TNFa treatment, topical and/or systemic...
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The treatment of systemic necrotizing vasculitis has made great strides in both efficacy and outcomes. Standard therapies, however, are associated with numerous side effects, and not all patients will respond to conventional immunosuppression. These realities have prompted the search for safer and more efficacious treatments, most notably among biologic agents. For example, the role of TNF-α in...
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ABOUT THE COVER " I think of my work as an inhabited landscape, never static or empty…. The wind ruffles; ants crawl; a rabbit burrows " (1). A painter of Salish, French-Cree, and Shoshone heritage, Jaune Quick-to-See Smith was born in St. Ignatius, Montana, and raised on the Flathead Reservation. She studied art at the University of New Mexico, but her personal aesthetic and her poetic associa...
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ژورنال
عنوان ژورنال: Eye
سال: 2009
ISSN: 0950-222X,1476-5454
DOI: 10.1038/eye.2009.203